Faculty

Dr. Shintaro KINUGAWA
Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan

Education:
1996-1999 Ph.D., Graduate School of Medical Sciences, Kyushu University
1988-1994 M.D., Department of Medicine, Kyushu University School of Medicine

Professional Training and Employment:
20012-Present Lecturer in Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Department of Cardiovascular Medicine
2007-2012 Research Associate in Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Department of Cardiovascular Medicine
2005-2007 Clinical Fellow in Hokkaido University Hospital, Department of Cardiovascular Medicine
2001-2005 Research Fellow in New York Medical College, Department of Physiology
1999-2001 Clinical Fellow in Cardiology, Hiroshima Red Cross and Atomic-Bomb Survivors Hospital
1994-1996 Resident in Internal Medicine, Kyushu University Hospital

Licence:
1994 The National Medical Practitioners Qualifying Examination
2001 Board Certified Member of the Japanese Society of Internal Medicine
2011 Board Certified Member of the Japanese Circulation Society
2012 Registered Instructor of Cardiac Rehabilitation
2016 Certified Physician of Cardiac Rehabilitation

Societies:
Japanese Society of Internal Medicine, Japanese Circulation Society, Japanese College of Cardiology, Japanese Heart Failure Society, Japanese Association of Cardiac Rehabilitation, Internal Society for Heart Research

Awards/Honors:
First Prize of Young Investigator Award for the 1st Annual Scientific Meeting of the Japanese Heart Failure Society
Kimura Noboru Award for Japanese Association of Cardiac Rehabilitation

Publication Lists:
Reviews

  1. Tsutsui H, Yamamoto S, Takahashi M, Ishibashi Y, Saito K, Kinugawa S, Tagawa H, Takeshita A:  Action of deuterium oxide on myocardial microtubules and contractility. J Deuterium Oxide Science, 1997.6(1);1-6
  2. Tsutsui H, Ide T, Kinugawa S: Mitochondrial oxidative stress, DNA damage, and heart failure. Antioxid Redox Signal, 2006.8;1737-1744
  3. Tsutsui H, Kinugawa S, Matsushima S: Mitochondrial oxidative stress and dysfunction in myocardial remodeling. Cardiovasc Res, 2009.81;449-56
  4. Tsutsui H, Tsuchihashi-Makaya M, Kinugawa S: Clinical characteristics and outcomes of heart failure with preserved ejection fraction: Lessons from epidemiological studies. J Cardiol, 2009.55;13-22
  5. Tsutsui H, Kinugawa S, Matsushima S, Yokota T: Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus. J Clin Biochem Nutr, 2011.48;68-71
  6. Tsutsui H, Kinugawa S, Matsushima S: Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol, 2011.301;H2181-H2190
  7. Okita K, Kinugawa S, Tsutsui H: Exercise intolerance in chronic heart failure. Circ J, 2013.77;293-300
  8. Kinugawa S, Takada S, Matsushima S, Okita K, Tsutsui H: Skeletal muscle abnormalities in heart failure. Int Heart J, 2015.56(5);475-484

Original Articles:

  1. Ishibashi Y, Urabe Y, Tsutsui H, Kinugawa S, Sugimachi M, Takahashi M, Yamamoto S, Tagawa H, Sunagawa K, Takeshita A: Negative inotropic effect of basic fibroblast growth factor on adult rat cardiac myocytes. Circulation, 1997.96(8);2501-2504
  2. Takahashi M, Tsutsui H, Kinugawa S, Igarashi-Saito K, Yamamoto S, Yamamoto M, Tagawa H, Imanaka-Yoshida K, Egashira K, Takeshita A: Role of microtubles in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy. J Mol Cell Cardiol, 1998.30(5);1047-1057
  3. Igarashi-Saito K, Tsutsui H, Yamamoto S, Takahashi M, Kinugawa S, Tagawa H, Usui M, Yamamoto M, Egashira K, Takeshita A: Role of sarcoplasmic reticulum-Ca2+ATPase in contractile dysfunction of myocytes in tachycardia-induced heart failure. Am J Physiol, 1998.275(1 Pt 2);H31-H40
  4. Kinugawa S, Tsutsui H, Satoh S, Takahashi M, Ide T, Igarashi-Saito K, Arimura K, Egashira K, Takeshita A: Role of Ca2+ availability to myofilaments and their sensitivity to Ca2+ in myocytes contractile dysfunction in heart failure. Cardiovasc Res, 1999.44(2);398-406
  5. Igarashi-Saito K, Tsutsui H, Takahashi M, Kinugawa S, Egashira K, Takeshita A: Endocardial versus epicardial differences of sarcoplasmic reticulum Ca2+-ATPase gene expression in the canine failing myocardium. Basic Res Cardiol, 1999.94(4);267-273
  6. Ide T, Tsutsui H, Kinugawa S, Utsumi H, Takeshita A: Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action. Circulation, 1999.100(7);690-692
  7. Ide T, Tsutsui H, Kinugawa S, Ustumi H, Kang D, Hattori N, Uchida K, Arimura K, Egashira K, Takeshita A: Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circ Res, 1999.85(4);357-363
  8. Satoh S, Kinugawa S, Tsutsui H, Takeshita A: Adrenoceptor-mediated regulation of myofibrillar Ca2+ sensitivity through the GTP-binding protein-related mechanisms: tension recording in beta-escin-skinned single rat cardiac cells with preserved receptor functions. Pflugers Arch-Eur J Physiol, 1999.437(5);702-709
  9. Kinugawa S, Tsutsui H, Ide T, Nakamura R, Arimura K, Egashira K, Takeshita A: Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes. Cardiovasc Res, 1999.43(1);157-164
  10. Kinugawa S, Tsutsui H, Hayashidani S, Ide T, Suematsu N, Satoh S, Utsumi H, Takeshita A: Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress. Circ Res, 2000.87(5);392-398
  11. Ide T, Tsutsui H, Kinugawa S, Suematsu N, Hayashidani S, Ichikawa K, Utsumi H, Machida Y, Egashira K, Takeshita A: Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium. Circ Res, 2000.86(2);152-157
  12. Suematsu N, Satoh S, Kinugawa S, Tsutsui H, Hayashidani S, Nakamura R, Egashira K, Makino N, Takeshita A: Alpha1-Adrenoceptor-Gq-RhoA signaling is upregulated to increase myofibrillar Ca2+ sensitivity in failing hearts. Am J Physiol Heart Circ Physiol, 2001.281(2);H637-H646
  13. Tsutsui H, Ide T, Hayashidani S, Kinugawa S, Suematsu N, Utsumi H, Takeshita A: Effects of ACE inhibition on left ventricular failure and oxidative stress in Dahl salt-sensitive rats. J Cardiovasc Pharmacol, 2001.37(6);725-733
  14. Tsutsui H, Kinugawa S, Ide T, Hayashidani S, Suematsu N, Satoh S, Nakamura R, Egashira K, Takeshita A: Positive inotropic effects of calcium sensitizers on normal and failing cardiac myocytes. J Cardiovasc Pharmacol, 2001.37(1);16-24
  15. Hayashidani S, Tsutsui H, Shiomi T, Suematsu N, Kinugawa S, Ide T, Wen J, Takeshita A: Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation, 2002.105(7);868-873
  16. Kinugawa S, Post H, Kaminski PM, Zhang X, Xu X, Huang H, Recchia FA, Ochoa M, Wolin MS, Kaley G, Hintze TH: Coronary microvascular endothelial stunning after acute pressure overload in the conscious dog is caused by oxidant processes: the role of angiotensin II type 1 receptor and NAD(P)H oxidase. Circulation, 2003.108(23);2934-2940
  17. Kinugawa S, Huang H, Wang Z, Kaminski PM, Wolin MS, Hintze TH: A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase. Circ Res, 2005.96(3);355-362
  18. Kinugawa S, Zhang J, Messina E, Walsh E, Huang H, Kaminski PM, Wolin MS, Hintze TH: Gp91phox-containing NAD(P)H oxidase mediates attenuation of nitric oxide-dependent control of myocardial oxygen consumption by ANG II. Am J Physiol Heart Circ Physiol, 2005.289(2);H862-H867
  19. Kinugawa S, Wang Z, Kaminski PM, Wolin MS, Edwards JG, Kaley G, Hintze TH: Limited exercise capacity in heterozygous manganese superoxide dismutase gene-knockout mice: roles of superoxide anion and nitric oxide. Circulation, 2005.111(2);1480-1486
  20. Ojaimi C, Li W, Kinugawa S, Post H, Csiszar A, Pacher P, Kaley G, Hintze TH: Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype. Am J Physiol Heart Circ Physiol, 2005.289(4);H1399-H1407
  21. Matsusaka H, Ide T, Matsushima S, Ikeuchi M, Kubota T, Sunagawa K, Kinugawa S, Tsutsui H: Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload. Hypertension, 2006.47(4);711-717
  22. Matsusaka H, Ide T, Matsushima S, Ikeuchi M, Kubota T, Sunagawa K, Kinugawa S, Tsutsui H: Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice. Cardiovasc Res, 2006.70(3);457-465
  23. Matsushima S, Ide T, Yamato M, Matsusaka H, Hattori F, Ikeuchi M, Kubota T, Sunagawa K, Hasegawa Y, Kurihara T, Oikawa S, Kinugawa S, Tsutsui H: Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice. Circulation, 2006.113(4);1779-1786
  24. Matsushima S, Kinugawa S, Ide T, Matsusaka H, Inoue N, Ohta Y, Yokota T, Sunagawa K, Tsutsui H: Overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart. Am J Physiol Heart Circ Physiol, 2006.291(5);H2337-H2345
  25. Matsusaka H, Kinugawa S, Ide T, Matsushima S, Shiomi T, Kubota T, Sunagawa K, Tsutsui H: Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction. J Cardiovasc Pharmacol, 2006.48(3);95-102
  26. Tsutsui H, Tsuchihashi-Makaya M, Kinugawa S, Goto D, Takeshita A; JCARE-CARD Investigators: Clinical characteristics and outcome of hospitalized patients with heart failure in Japan. Circ J, 2006.70(12);1617-1623
  27. Suematsu N, Ojaimi C, Kinugawa S, Wang Z, Xu X, Koller A, Recchia FA, Hintze TH: Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress. Circulation, 2007.115(2);255-262
  28. Tsutsui H, Tsuchihashi-Makaya M, Kinugawa S, Goto D, Takeshita A; JCARE-GENERAL Investigators: Characteristics and outcomes of patients with heart failure in general practices and hospitals. Circ J, 2007.71(4);449-454
  29. Tsutsui H, Matsushima S, Kinugawa S, Ide T, Inoue N, Ohta Y, Yokota T, Hamaguchi S, Sunagawa K: Angiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart. Hypertens Res, 2007.30(5);439-449
  30. Yamato M, Shiba T, Yoshida M, Ide T, Seri N, Kudou W, Kinugawa S, Tsutsui H: Fatty acids increase the circulating levels of oxidative stress factors in mice with diet-induced obesity via redox changes of albumin. FEBS J, 2007.274(15);3855-3863
  31. Suga T, Okita K, Morita N, Yokota T, Hirabayashi K, Horiuchi M, Takada S, Takahashi T, Omokawa M, Kinugawa S, Tsutsui H: Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction. J Appl Physiol, 2009.106(4);1119-1124
  32. Matsushima S, Kinugawa S, Yokota T, Inoue N, Ohta Y, Hamaguchi S, Tsutsui H: Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes. Am J Physiol Heart Circ Physiol, 2009.297(1);H409-H416
  33. Hamaguchi S, Tsuchihashi-Makaya M, Kinugawa S, Yokota T, Ide T, Takeshita A, Tsutsui H; JCARE-CARD Investigators: Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan. Circ J, 2009.73(8);1442-1447
  34. Yokota T, Kinugawa S, Hirabayashi K, Matsushima S, Inoue N, Ohta Y, Hamaguchi S, Sobirin MA, Ono T, Suga T, Kuroda S, Tanaka S, Terasaki F, Okita K, Tsutsui H: Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice. Am J Physiol Heart Circ Physiol, 2009.297(3);1069-1077
  35. Tsuchihashi-Makaya M, Hamaguchi S, Kinugawa S, Yokota T, Goto D, Yokoshiki H, Kato N, Takeshita A, Tsutsui H; JCARE-CARD Investigators: Characteristics and outcomes of hospitalized patients with heart failure and reduced vs preserved ejection fraction. Circ J, 2009.73(10);1893-1900
  36. Hamaguchi S, Tsuchihashi-Makaya M, Kinugawa S, Yokota T, Takeshita A, Yokoshiki H, Tsutsui H; JCARE-CARD Investigators: Anemia is an independent predictor of long-tern adverse outcomes in patients hospitalized with heart failure in Japan. Circ J, 2009.73(10);1901-1908
  37. Hamaguchi S, Yokoshiki H, Kinugawa S, Tsuchihashi-Makaya M, Yokota T, Takeshita A, Tsutsui H; JCARE-CARD Investigators: Effects of atrial fibrillation on long-term outcomes in patients hospitalized for heart failure in Japan. Circ J, 2009.73(11);2084-2090
  38. Tsuchihashi-Makaya M, Furumoto T, Kinugawa S, Hamaguchi S, Goto K, Goto D, Yamada S, Yokoshiki H, Takeshita A, Tsutsui H; JCARE-CARD Investigators: Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure. Hypertens Res, 2010.33(3);197-202
  39. Hokari M, Kuroda S, Kinugawa S, Ide T, Tsutsui H, Iwasaki Y: Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice. Neuropathology, 2010.30(4);401-407
  40. Horiuchi M, Okita K, Takada S, Omokawa M, Suga T, Morita N, Hirabayashi K, Yokota T, Kinguawa S, Tsutsui H: Effects of oral single-dose administration of sarpogrelate hydrochloride on saturation o2 of calf muscle during plantar flexion exercise. Adv Exp Med Biol, 2010.662;531-536
  41. Suga T, Okita K, Morita N, Yokota T, Hirabayashi K, Horiuchi M, Takada S, Omokawa M, Kinugawa S, Tsutsui H: Does effect on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction. J Appl Physiol, 2010.108(6);1563-1567
  42. Tsuchihashi-Makaya M, Kinugawa S, Yokoshiki H, Hamaguchi S, Yokota T, Goto D, Goto K, Takeshita A, Tsutsui H; JCARE-CARD Investigators: Beta-blocker use at discharge in patients hospitalized for heart failure is associated with improved survival. Circ J, 2010.74(7);1364-1371
  43. Ojaimi C, Kinugawa S, Recchia FA, Hintze TH: Oxidant-NO dependent gene regulation in dogs with type I diabetes: impact on cardiac function and metabolism. Cardiovasc Diabetol, 2010.9;43-52
  44. Miura Y, Fukumoto Y, Shiba N, Miura T, Shimada K, Iwama Y, Takagi A, Matsusaka H, Tsutsumi T, Yamada A, Kinugawa S, Asakura M, Okamatsu S, Tsutsui H, Daida H, Matsuzaki M, Tomoike H, Shimokawa H: Prevalence and clinical implication of metabolic syndrome in chronic heart failure. Circ J, 2010.74(12);2612-2621
  45. Hamaguchi S, Tsuchihashi-Makaya M, Kinugawa S, Goto D, Yokota T, Goto K, Yamada S, Yokoshiki H, Takeshita A, Tsutsui H; for the JCARE-CARD Investigators: Body mass index is an independent predictor of long-term outcomes in patients hospitalized with heart failure in Japan. Circ J, 2010.74(12);2605-2611
  46. Hamaguchi S, Kinugawa S, Tsuchihashi-Makaya M, Goto K, Goto D, Yokota T, Yamada S, Yokoshiki H, Takeshita A, Tsutsui H: Spironolactone use at discharge was associated with improved survival in hospitalized patients with systolic heart failure. Am Heart J, 2010.160(6);1156-1162
  47. Hamaguchi S, Furumoto T, Tsuchihashi-Makaya M, Goto K, Goto D, Yokota T, Kinugawa S, Yokoshiki H, Takeshita A, Tsutsui H; for the JCARE-CARD Investigators: Hyperuricemia predicts adverse outcomes in patients with heart failure. Int J Cardiol, 2011.151;143-147
  48. Ohta Y, Kinugawa S, Matsushima S, Ono T, Sobirin MA, Inoue N, Yokota T, Hirabayashi K, Tsutsui H: Oxidative stress impairs insulin signal in skeletal muscle and causes insulin resistance in postinfarct heart failure. Am J Physiol Heart Circ Physiol, 2011.300(5);H1637-H1644
  49. Tsuchihashi-Makaya M, Hamaguchi S, Kinugawa S, Goto K, Goto D, Furumoto T, Yamada S, Yokoshiki H, Takeshita A, Tsutsui H: Sex differences with respect to clinical characteristics, treatment, and long-term outcomes in patients with heart failure. Int J Cardiol, 2011.150(3);338-339
  50. Yokota T, Kinugawa S, Okita K, Hirabayashi K, Suga T, Hattori M, Nakagawa Y, Oyama-Manabe N, Shirato H, Tsutsui H: Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome. Hypertens Res, 2011.34(9);1029-1034
  51. Hamaguchi S, Kinugawa S, Goto D, Tsuchihashi-Makaya M, Yokota T, Yamada S, Yokoshiki H, Takeshita A, Tsutsui H; JCARE-CARD Investigators: Predictors of long-term adverse outcomes in elderly patients over 80 years hospitalized with heart failure. Circ J, 2011.75(10);2403-2410
  52. Takada S, Okita K, Suga T, Omokawa M, Morita N, Horiuchi M, Kadoguchi T, Takahashi M, Hirabayashi K, Yokota T, Kinugawa S, Tsutsui H: Blood flow restriction exercise in sprinters and endurance runners. Med Sci Sports Exerc, 2012.44(3);413-419
  53. Yamato M, Shiba T, Ide T, Seri N, Kudo W, Ando M, Yamada K, Kinugawa S, Tsutsui H: High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice. Mol Cell Biochem, 2012.359(1-2);161-7
  54. Inoue N, Kinugawa S, Suga T, Yokota T, Hirabayashi K, Kuroda S, Okita K, Tsutsui H: Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle. Am J Physiol Heart Circ Physiol, 2012.302(5);H1202-H1210
  55. Suga T, Okita K, Takada S, Omokawa M, Kadoguchi T, Yokota T, Hirabayashi K, Takahashi M, Morita N, Horiuchi M, Kinugawa S, Tsutsui H: Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction. Eur J Appl Physiol, 2012.112(11);3915-3920
  56. Hamaguchi S, Kinugawa S, Sobirin MA, Goto D, Tsuchihashi-Makaya M, Yamada S, Yokoshiki H, Tsutsui H; JCARE-CARD Investigators: Mode of death in patients with heart failure and reduced vs preserved ejection fraction. Circ J, 2012.76(7);1662-1669
  57. Takada S, Okita K, Suga T, Omokawa M, Kadoguchi T, Sato T, Takahashi M, Yokota T, Hirabayashi K, Morita N, Horiuchi M, Kinugawa S, Tsutsui H: Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions. J Appl Physiol, 2012.113(2);199-205
  58. Hamaguchi S, Kinugawa S, Tsuchihashi-Makaya M, Goto D, Yamada S, Yokoshiki H, Takeshita A, Tsutsui H; JCARE-CARD Investigators: Loop diuretic use at discharge is associated with adverse outcomes in hospitalized patients with heart failure. Circ J, 2012.76(8);1920-1907
  59. Sobirin MA, Kinugawa S, Takahashi M, Fukushima A, Homma T, Ono T, Hirabayashi K, Suga T, Azalia P, Takada S, Taniguchi M, Nakayama T, Ishimori N, Iwabuchi K, Tsutsui H: Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice. Circ Res, 2012.111(8);1037-47
  60. Goto D, Kinugawa S, Hamaguchi S, Sakakibara M, Tsuchihashi-Makaya M, Yokota T, Yamada S, Yokoshiki H, Tsutsui H; JCARE-CARD Investigators: Clinical characteristics and outcomes of dilated phase of hypertrophic cardiomyopathy: Report from the registry data in Japan. J Cardiol, 2013.61(1);65-70
  61. Takada S, Kinugawa S, Hirabayashi K, Suga T, Yokota T, Takahashi M, Fukushima A, Homma T, Ono T, Sobirin MA, Masaki Y, Kodoguchi T, Okita K, Tsutsui H: Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice. J Appl Physiol, 2013.114(7);844-857
  62. Yokota T, Kinugawa S, Yamato M, Hirabayashi K, Suga T, Takada S, Harada K, Morita N, Oyama-Manabe N, Kikuchi Y, Okita K, Tsutsui H: Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with metabolic syndrome. Diabetes Care, 2013.36(5);1341-1346
  63. Tsuchihashi-Makaya M, Matsuo H, Kakinoki S, Takechi S, Kinugawa S, Tsutsui H; J-HOMECARE Investigators: Home-based disease management program to improve psychological status in patients with heart failure in Japan. Circ J, 2013.77(4);926-33
  64. Hamaguchi S, Kinugawa S, Tsuchihashi-Makaya M, Goto D, Yamada S, Yokoshiki H, Tsutsui H: Characteristics, management, and outcomes for patients during hospitalization due to worsening heart failure-A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD). J Cardiol, 2013.62(2);95-101
  65. Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Abe T, Suga T, Takada S, Kadoguchi T, Okita K, Matsushima S, Tsutsui H: Increased plasma soluble (pro)renin receptor levels are correlated with renal dysfunction in patients with heart failure. Int J Cardiol, 2013.168(4);4313-4314
  66. Homma T, Kinugawa S, Takahashi M, Sobirin MA, Saito A, Fukushima A, Suga T, Takada S, Kadoguchi T, Masaki Y, Furihata T, Taniguchi M, Nakayama T, Ishimori N, Iwabuchi K, Tsutsui H: Activation of invariant natural killer T cells by α-galactosylceramide ameliorates myocardial ischemia/reperfusion injury in mice. J Mol Cell Cardiol, 2013.62;179-188
  67. Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Abe T, Suga T, Takada S, Kadoguchi T, Katsuyama R, Oba K, Okita K, Tsutsui H: Decreased serum brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure. Int J Cardiol, 2013.168(5);e142-e144
  68. Ishimori N, Kinugawa S, Yamada S, Yokoshiki H, Mitsuyama H, Tsutsui H: Report of the American Heart Association (AHA) Scientific Sessions 2013, Dallas. Circ J, 2014.78(1);51-56
  69. Fujita T, Fujino N, Anan R, Tei C, Kubo T, Doi Y, Kinugawa S, Tsutsui H, Kobayashi S, Yano M, Asakura M, Kitakaze M, Komuro I, Konno T, Hayashi K, Kawashiri MA, Ino H, Yamagishi M: Sarcomere gene mutations are associated with increased cardiovascular events in left ventricular hypertrophy: results from multicenter registration in Japan. JACC Heart Fail, 2013.1(6);459-466
  70. Suga T, Kinugawa S, Takada S, Kadoguchi T, Fukushima A, Homma T, Masaki Y, Furihata T, Takahashi M, Sobirin MA, Ono T, Hirabayashi K, Yokota T, Okita K, Tsutsui H: Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice. Endocrinology, 2014.155(1);68-80
  71. Hamaguchi S, Kinugawa S, Tsuchihashi-Makaya M, Goto D, Tsutsui H: Weekend versus weekday hospital admission and outcomes during hospitalization for patients due to worsening heart failure: a report from Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD). Heart Vessels, 2014.29(3);328-335
  72. Hamaguchi S, Kinugawa S, Tsuchihashi-Makaya M, Matsushima S, Sakakibara M, Ishimori N, Goto D, Tsutsui H: Hyponatremia is an independent predictor of adverse clinical outcomes in hospitalized patients due to worsening heart failure. J Cardiol, 2014.63(3);182-188
  73. Imamura T, Kinugawa K, Ohtani T, Sakata Y, Higo T, Kinugawa S, Tsutsui H, Sunagawa K, Komuro I: Assessment of quality of life during long-term treatment of tolvaptan in refractory heart failure. Int Heart J, 2104.55;264-7
  74. Takada S, Hirabayashi K, Kinugawa S, Yokota T, Matsushima S, Suga T, Kadoguchi T, Fukushima A, Homma T, Mizushima W, Masaki Y, Furihata T, Katsuyama R, Okita K, Tsutsui H: Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice. Eur J Pharmacol, 2014.740;690-696
  75. Hamaguchi S, Kinugawa S, Matsushima S, Fukushima A, Yokota T, Sakakibara M, Yokoshiki H, Tsuchihashi-Makaya M, Tsutsui H; JCARE-CARD Investigators: Clinical characteristics and CHADS2 score in patients with heart failure and atrial fibrillation. Int J Cardiol, 2014.176(1):239-242
  76. Fukushima A, Kinugawa S, Takada S, Matsushima S, Sobirin MA, Ono T, Takahashi M, Suga T, Homma T, Masaki Y, Furihata T, Kadoguchi T, Yokota T, Okita K, Tsutsui H: (Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice. Am J Physiol Endocrinol Metab, 2014.307(6):E503-14
  77. Hirabayashi K, Kinugawa S, Yokota T, Takada S, Fukushima A, Suga T, Takahashi M, Ono T, Morita N, Omokawa M, Harada K, Oyama-Manabe N, Shirato H, Matsushima S, Okita K, Tsutsui H: Intramyocellular lipid is increased in the skeletal muscle of patients with dilated cardiomyopathy with lowered exercise capacity. Int J Cardiol, 2014.176(3):1110-2
  78. Kadoguchi T, Kinugawa S, Takada S, Fukushima A, Furihata T, Homma T, Masaki Y, Mizushima W, Nishikawa M, Takahashi M, Yokota T, Matsushima S, Okita K, Tsutsui H: Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle. Exp Physiol, 2015. 100(3):312-22
  79. Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Takada S, Kadoguchi T, Oba K, Okita K, Tsutsui H: Serum brain-derived neurotrophic factor level predicts adverse clinical outcomes in patients with heart failure. J Card Fail, 2015. 21(4):300-306
  80. Nishikawa M, Ishimori N, Takada S, Saito A, Kadoguchi T, Furihata T, Fukushima A, Matsushima S, Yokota T, Kinugawa S, Tsutsui H: AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress. Nephrol Dial Transplant, 2015. 30(6):934-942
  81. Ono T, Takada S, Kinugawa S, Tsutsui H: Curcumin ameliorates skeletal muscle atrophy in type I diabetic mice via inhibiting the protein ubiqutination. Exp Physiol, 2015. 100(9):1052-63
  82. Takahashi M, Kinugawa S, Takada S, Hirabayashi K, Yokota T, Matsushima S, Saito A, Okita K, Tsutsui H: Low-intensity exercise under ischemic conditions enhances metabolic stress in patients with heart failure. Int J Cardiol, 2015. 201:142-144
  83. Takada S, Kinugawa S, Matsushima S, Takemoto D, Furihata T, Mizushima W, Fukushima A, Yokota T, Ono Y, Shibata H, Okita K, Tsutsui H: Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes. Exp Physiol, 2015. 100(11):1319-30
  84. Furihata T, Kinugawa S, Matsushima S, Takada S, Fukushima A, Takahashi M, Tsuda M, Matsumoto J, Homma T, Masaki Y, Yokota T, Tsutsui H: The experimental model of transition from compensated cardiac hypertrophy to faiure created by transverse arortic constrication in mice. IJC Heart & Vasculature, 2016, in press
  85. Fukushima A, Kinugawa S, Takada S, Matsumoto J, Furihata T, Mizushima W, Tsuda M, Yokota T, Matsushima S, Okita K, Tsutsui H: Direct renin inhibitor ameliorated insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice. Eur J Pharmacol, 2016. 779;147-56
  86. Furihata T, Kinugawa S, Fukushima A, Takada S, Homma T, Masaki Y, Abe T, Oba K, Okita K, Tsutsui H: Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure. Int J Cardiol, 2016. 220;483-487
  87. Takada S, Masaki Y, Kinugawa S, Matsumoto J, Furihata T, Mizushima W, Kadoguchi T, Fukushima A, Homma T, Takahashi M, Harashima S, Matsushima S, Yokota T, Tanaka S, Okita K, Tsutsui H: Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of GLP-1 receptor signaling. Cardiovasc Res, 2016. 111;338-47
  88. Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N, Oka S, Yokota T, Kinugawa S, Hsu CP, Li H, Tsutsui H, Sadoshima J: Fyn is a physiological regulator of Nox4 in the heart. J Clin Invest, 2016. 126(9);3403-16
  89. Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nakayama KI, Tsutsui H, Hatakeyama S: The novel heart-specific RING finger protein 207 regulates energy metabolism in cardiomyocytes. J Moll Cell Cardiol, 2016. 100;43-53
  90. Yokota T, Kinugawa S, Hirabayashi K, Suga T, Takada S, Omokawa M, Kadoguchi T, Takahashi M, Fukushima A, Okita K, Tsutsui H: Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome. J Diabetes Invest, 2016, in press

 

 

 

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